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Pharmacogenomic Testing (PGx)

Right Patient. Right Medication. Right Time.

Vanguard Comprehensive Pharmacogenomics (PGx) Panel

ABOUT

PGx identifies genetic factors that are linked to drug metabolism that impact the efficacy, safety, and tolerability of commonly prescribed medications.

IDEAL PATIENT

This test is for people taking multiple medications or who have a history of medication failures or adverse drug reactions.

FAST FACTS

COMPREHENSIVE

Panel includes 19 genes and over
12 therapeutic classes

SIMPLE

Noninvasive DNA test using
a cheek swab

FAST

Results returned within 2 weeks of receipt at the lab

ADVERSE DRUG REACTIONS

Adverse drug reactions (ADRs) are a significant public health problem. Over 2 million ADRs occur each year, resulting in over 100,000 deaths, making ADRs the fourth leading cause of death in the U.S.¹

Adverse drug reactions (ADRs) are a significant public health problem. Over 2 million ADRs occur each year, resulting in over 100,000 deaths, making ADRs the fourth leading cause of death in the U.S.¹

FAILED DRUG TRIALS

Drug response can be unpredictable, leaving patients symptomatic and frustrated when their medications are ineffective.

Average % of population that a drug class is innefective.

Genetics Play An Important Role In Drug Response

90%

Of people carry a genetic variant that may impact how they respond to drugs³

300+

Drugs have an FDA label
with PGx information³

60%

Of medication prescribed in a primary care office have PGx recommendations4-6

Drugs Associated With Genetic Variability Are Common

Most commonly prescribed medications.

“Knowledge of a patient’s genotype may be used to aid in determining a therapeutic strategy, determining an appropriate dosage, or assessing the likelihood of benefit or toxicity.”

– FDA 2022

The Clinical Pharmacogenetics Implementation Consortium (CPIC®)* is an international alliance of dedicated volunteers and a team who share a common goal: to advance the adoption of pharmacogenetic testing in patient care.

For the pharmacogenetic associations listed in this table, the FDA** has evaluated and believes there is sufficient scientific evidence to suggest that subgroups of patients with certain genetic variants, or genetic variant-inferred phenotypes (such as affected subgroup in the table below), are likely to have altered drug metabolism, and in certain cases, differential therapeutic effects, including differences in risks of adverse events.

Adverse Drug Reactions are Preventable

Many commonly prescribed drugs are associated with genetic variation that directly impact the efficacy and safety of that drug.

PGX CAN REDUCE AND MINIMIZE FAILED DRUG TRIALS

PGx takes the guessing out of prescribing by identifying a patient’s genetic factors that directly impact how they metabolize and respond to certain medications. We help healthcare providers optimize drug treatment by determining the patient’s expected outcome.

The Vanguard PGx Panel Is...

Evidence Based

Gene and drug curation based on up-to-date FDA guidance*

Comprehensive

A range of therapeutic areas with direct gene-drug interactions

Actionable

Medications categorized by personalized predicted drug response

We are a full service laboratory and our menu or tests and services are expanding.

For a comprehensive list of tests and services, call us today at 918-212-6177.